NAD+ IV Therapy

What NAD+ Does in the Body

NAD+ is known as a “helper molecule” because it binds to enzymes and enables them to perform vital biological functions. One important family of enzymes that depend on NAD+ are sirtuins which play a key role in cellular repair metabolism and aging.

Biological Processes Supported by NAD+

• DNA repair and cellular protection
• Gene expression
• Energy production within mitochondria
• Chromosomal stability
• Calcium signaling
• Epigenetic and post-translational modifications

In simple terms NAD+ keeps your cells functioning efficiently. As levels naturally decline with age replenishing NAD+ may help restore cellular vitality and overall well-being.

What is NAD+ IV Therapy?

NAD+ IV therapy delivers this coenzyme directly into your bloodstream through a controlled intravenous infusion. This method provides the highest and most predictable absorption compared to oral supplements which are largely broken down by the digestive system before they can be utilized by your cells.

Infusions can last between 2 to 8 hours depending on the dose and your individual goals. Most patients benefit from a series of treatments rather than a single infusion.

Other Ways to Support NAD+: Oral and Injectable Options

Because NAD+ has become widely discussed many patients ask about alternatives to IV therapy. Below is a clear comparison of the main options so you can make an informed decision.

At Glendale Whole Health we offer all clinically used forms of NAD support including IV NAD+ injectable NAD+ (SQ and IM) and oral NAD+ precursors such as NR and NMN. Your personalized plan may include one or more of these options depending on your goals symptoms and response to treatment.

Oral NAD+ (Capsules or Powder)

Oral NAD+ supplements are available over the counter but they have important limitations.

When you swallow NAD+ most of it is broken down in the gut before it can reach your bloodstream. As a result only a small and variable amount reaches your cells. This makes dosing inconsistent and results less predictable.

Pros

• Convenient
• Widely available
• Lower upfront cost

Cons

• Poor and inconsistent absorption
• Uncertain increase in actual tissue NAD+ levels
• Typically less noticeable clinical effect than IV

Bottom line: Oral NAD+ may support general wellness but it is not considered equivalent to IV therapy for therapeutic purposes.

Oral NAD+ Precursors (NR and NMN)

Instead of taking NAD+ directly some people take NAD+ precursors most commonly:

• NR (Nicotinamide Riboside)
• NMN (Nicotinamide Mononucleotide)

These compounds are converted by the body into NAD+.

Research suggests that NR and NMN can increase intracellular NAD+ levels to some degree especially with consistent daily use. They are often used as a maintenance strategy for energy brain health and longevity.

Pros

• Easier to take than IV
• Daily steady support
• Better absorption than oral NAD+ itself

Cons

• Slower and more modest effects than IV
• Requires long-term daily use
• Not ideal for acute needs such as fatigue brain fog recovery or addiction support

How we think about them at Glendale Whole Health:
We often view NR or NMN as a long-term maintenance tool while IV NAD+ is used for faster more noticeable support or clinical situations.

Injectable NAD+ (IM or Subcutaneous/SQ)

NAD+ can also be administered by injection either:

• Intramuscular (IM) — into the muscle
• Subcutaneous (SQ) — under the skin

This method bypasses the gut which is an advantage over oral supplementation. However it still does not deliver NAD+ as directly or efficiently as IV therapy.

Pros

• Better absorption than oral
• More convenient than IV
• Can be done more frequently if needed

Cons

• Limited volume per injection
• Typically lower total dose than IV
• Effects are usually milder than IV infusions

Injectable NAD+ is sometimes used for:

• Maintenance between IV sessions
• Patients who cannot sit for long infusions
• Individuals who prefer more frequent lower-dose support

SQ vs IM NAD+: How We Think About It

Both subcutaneous (SQ) and intramuscular (IM) NAD+ bypass the gut making them more reliable than oral NAD. However they behave differently in the body.

Why we generally prefer SQ for NAD+

Subcutaneous NAD+ is absorbed more slowly and steadily into the bloodstream. This tends to produce smoother more consistent effects with fewer side effects such as flushing nausea or feeling overly stimulated. Because it is usually more comfortable and easier to tolerate SQ is often better suited for:

• Maintenance between IV sessions
• Patients who prefer more frequent lower-dose support
• Individuals who are sensitive to NAD+ or prone to infusion-related discomfort
• Longer-term use as a “bridge” therapy when IV is not practical

When IM NAD+ may be appropriate

Intramuscular NAD+ delivers the coenzyme more quickly than SQ which can feel more noticeable in the short term. For some patients this can be helpful as an occasional “boost.” IM may be considered when:

• A patient prefers a single more immediate dose
• Higher single-site dosing is desired
• The patient tolerates IM injections well and reports better subjective benefit

However because IM absorption is faster and sometimes less predictable it can feel more activating and is less commonly used for routine maintenance than SQ.

How this fits with our overall approach

At Glendale Whole Health we view:

• IV NAD+ as the most reliable option for therapeutic loading cognitive reset significant fatigue or addiction support
• SQ NAD+ as our preferred injectable option for maintenance or more frequent support
• IM NAD+ as an alternative option in select cases based on patient preference and response

How to Choose: IV vs Oral vs Injectable (SQ vs IM)

Method	Best For	Speed of Effect	Convenience	Typical Use	Why we use it / How it behaves
IV NAD+	Brain fog significant fatigue recovery neurological/mitochondrial goals addiction support	Fast and reliable	Least convenient (long infusions)	Loading and clinical therapy	Delivers NAD+ directly into circulation with highest and most predictable bioavailability
Injectable NAD+ (SQ)	Maintenance frequent lower-dose support sensitive patients bridge between IV sessions	Moderate smoother onset	Moderate	Ongoing support or maintenance	Preferred injectable method — slower steadier absorption tends to feel smoother and more tolerable
Injectable NAD+ (IM)	Occasional “boosts” or when a single more immediate dose is desired	Faster than SQ more variable	Moderate	Select cases based on preference	Absorbs more quickly than SQ and can feel more activating
Oral NR/NMN (precursors)	Long-term wellness and longevity	Slow gradual	Most convenient	Daily maintenance	Converted by the body into NAD+ over time more subtle than IV or injectables
Oral NAD+	General supplementation interest	Slow/variable	Convenient	Not preferred for clinical goals	Much of it is broken down in the gut making effects inconsistent

 

Potential Benefits of NAD+ IV Therapy

While individual results vary many patients report:

• Improved mental clarity and focus
• Reduced brain fog
• Increased energy and stamina
• Better metabolic efficiency
• Support for mitochondrial function
• Reduced inflammation
• Faster recovery from physical or neurological stress
• More stable mood and resilience to stress

Benefits for the Brain and Nervous System

NAD+ plays a key role in neuronal energy metabolism. Many patients describe feeling mentally sharper more focused and less cognitively fatigued after treatment.

By supporting cellular energy production in the brain NAD+ may help improve concentration memory and overall cognitive performance. Some individuals also report improvements in anxiety mood stability and mental endurance.

Benefits for Energy and Metabolism

NAD+ supports mitochondrial function which is essential for cellular energy production. This can translate into increased physical stamina improved endurance and better recovery after exercise or illness.

Because NAD+ is also involved in metabolic pathways replenishing it may support healthy blood sugar regulation and overall metabolic efficiency.

Other Physical Benefits

Since NAD+ is one of your body’s natural coenzymes that promotes cellular repair and resilience IV supplementation may:

• Reduce oxidative stress
• Support tissue recovery after injury
• Assist DNA repair through activation of PARP enzymes
• Support overall cellular turnover and regeneration

Who Is a Good Candidate for NAD+ IV Therapy?

NAD+ IV therapy may be beneficial for individuals who experience:

• Chronic fatigue or low energy
• Brain fog or difficulty concentrating
• Age-related cognitive changes
• Athletic performance or recovery goals
• Chronic inflammation or autoimmune concerns
• Neurological conditions
• Metabolic concerns
• Mood disorders or stress-related symptoms

It is often used as a wellness therapy for healthy individuals seeking longevity support as well as for those managing chronic conditions.

NAD+ IV Therapy May Be Helpful For:

• Alzheimer’s disease
• Parkinson’s disease
• Heart disease
• Diabetes
• Mitochondrial dysfunction
• Multiple sclerosis
• Fibromyalgia
• Anxiety or depression
• Chronic fatigue
• Memory or concentration issues

NAD+ is used as supportive therapy and does not replace standard medical care for these conditions.

NAD+ Therapy and Addiction: Can It Be Used for Recovery?

Intravenous NAD+ has been used in some medical and integrative settings as an adjunctive tool in substance use recovery including both opioid use disorder (OUD) and alcohol use disorder (AUD). It is not a stand-alone treatment for addiction and does not replace medical detox medication-assisted treatment or behavioral therapy when indicated.

Research suggests NAD+ may support recovery by:

• Improving cellular energy in the brain and nervous system
• Potentially reducing withdrawal-related fatigue and discomfort
• Supporting mental clarity and mood stability during early recovery
• Promoting overall neurological resilience after substance exposure

Some studies have explored NAD+ in opioid dependence with observations that it may help reduce withdrawal symptoms in certain individuals. Emerging data also suggest potential benefit in alcohol-related neuroinflammation and cravings though responses vary and research is still evolving.

At Glendale Whole Health we use NAD+ as supportive therapy alongside appropriate medical care and recovery planning. Patients with significant withdrawal symptoms or medical instability may require a higher level of care than outpatient IV therapy alone.

Who Should NOT Receive NAD+ IV Therapy?

NAD+ IV therapy may not be appropriate for individuals with:

• Uncontrolled high blood pressure
• Active psychosis or severe psychiatric instability
• Certain heart rhythm disorders
• Pregnancy or breastfeeding
• Active intoxication requiring medical detox
• Unstable medical conditions
• History of severe adverse reactions to IV infusions

A medical consultation is required before treatment.

How Much NAD+ Do I Need?

General Health and Anti-Aging

• 200–400 mg (1–2 hour infusion)
• Loading: Once weekly for 4 weeks
• Maintenance: Every 1–3 months

Enhanced Mind and Body for Medical Conditions

• 500–600 mg (2–4 hour infusion)
• Loading: Once weekly for 4 weeks
• Maintenance: Every 1–3 months

Drug and Alcohol Addiction and Recovery

Single Infusion (Trial Option)

• NAD+ 1000 mg (4–8 hour infusion)
  Best for patients who want to assess their response before committing to a multi-day program.

5-Day Treatment Program (Recommended Starting Point)

Loading Phase:

• Day 1: 1000 mg (4–8 hours)
• Day 2: 800 mg (4–6 hours)
• Days 3–5: 500 mg daily (2–4 hours each day)

Bridge Phase / Transition to Maintenance (After 5-Day Program)

To transition from the 5-day loading phase into long-term maintenance we typically use a minimum two-month bridge period before settling into ongoing maintenance. This allows the brain and nervous system to stabilize while gradually reducing frequency.

Bridge Phase (2 months minimum)

• Month 1 (higher frequency support):
  • 1000 mg twice per week
• Month 2 (step-down):
  • 500 mg twice per month
• If recovery goals are not yet fully met Month 2 can be extended as needed.

Maintenance (after Bridge Phase)

• Typical maintenance dosing range: 500–1000 mg per session individualized based on response.
• More aggressive: Once monthly
• Less aggressive: Once quarterly
• Maintenance frequency can be individualized over time based on symptoms stress load and recovery progress.

What to Expect During Treatment

All NAD+ infusions at Glendale Whole Health are administered under medical supervision. Vital signs are assessed before treatment and monitored during treatment as needed. Patients are screened for contraindications prior to infusion.

You may experience mild side effects such as headache nausea flushing or chest tingling/pressure during infusion which are typically transient and resolve with adjustments to infusion rate.

What You May Experience After NAD+ Treatment

Many patients report:

• Increased energy
• Clearer thinking and sharper memory
• Reduced pain or inflammation
• Improved mood and emotional balance
• Better exercise recovery
• Greater endurance
• Overall feeling of vitality and youthfulness

NAD+ IV Therapy Pricing

Required physician clearance visit: $150

Pricing Rule:

• 200 mg — $499
• Each additional 100 mg — + $100

Examples:

• 200 mg — $499
• 300 mg — $599
• 400 mg — $699
• 500 mg — $799
• 600 mg — $899
• 700 mg — $999
• 800 mg — $1,099
• 900 mg — $1,199
• 1000 mg — $1,299

5-Day Addiction Support Program — $4,500
Includes:

• Five NAD+ infusions (1000 → 800 → 500 x 3)
• Medical intake and daily monitoring
• Symptom assessment each day
• Follow-up check-in within 7–10 days

Ready to Get Started?

Glendale Whole Health offers personalized NAD+ IV therapy tailored to your health goals. Whether you are interested in anti-aging cognitive support metabolic health or addiction recovery we will work with you to design the most appropriate plan.

Schedule a consultation today:
(818) 551-0464
info@glendalewholehealth.com